A research assistant position is available for 2 years in the laboratory of Prof Sherif El-Khamisy, the Director of the Institute of Cancer Therapeutics (ICT) at the University of Bradford. The ICT houses a number of multidisciplinary research groups working together to research, develop and commercialise new treatments. The work spans fundamental discovery science to identify and validate new targets, synthetic and medicinal chemistry, pre-clinical pharmacology (including in vivo biology), molecular biology, drug metabolism and pharmacokinetics (DMPK), drug formulation and proteomics. We are one of only a few centres in the UK with the research tools and expertise in-house to progress medicines and biomarkers from concept to clinic.
The candidate will help support establishing a new lab at the ICT, work closely with researchers in the established areas of research interest and interface with the Faculty of Life Sciences to address fundamental questions underpinning oxidative stress and the abortive activities of endogenous enzymes such as topoisomerases. These breaks are among the most common types of DNA lesions arising in cells and we have shown their utility to treat cancer (Fielden et al., Nature Communications 2020, Liao et al, Cell Reports, 2018, Chiang et al, Science Advances 2017, El-Khamisy et al., Nature Rev Cancer 2015, Gómez-Herreros et al, Nature Genetics, 2014, Hudson et al, Nature Comm, 2012, El-Khamisy et al., Nature, 2005).
The candidate is expected to facilitate collaborations within the University of Bradford and beyond, such as the University of Oxford and the Healthy Lifespan Institute at the University of Sheffield. The project forms a part of the major strategic investment, with researchers working collaboratively across the chemical, biological and clinical sciences to translate the fundamental research discoveries into potential new medicines.
An ability to thrive in a cross-disciplinary research team and broad experience in cell culture and molecular biology techniques is essential. Experience in siRNA, mitochondrial assays, and chromatin IP are desirable, but enthusiasm and adaptability are more important. Candidates must be able to demonstrate a high level of motivation and ability to manage a research lab to deliver high quality research outputs. A PhD in molecular biology/biochemistry/cell biology is desirable but not essential.
For additional enquiries please contact email@example.com
Closing Date: 26 Aug 2022 Category: Research