Research Scientist - PNAC - Dr Phil Holliger - LMB 1854

Overall purpose:

To work within the Group of Dr Philipp Holliger at the MRC Laboratory of Molecular Biology (LMB), on a programme aimed at solving the structure(s) of RNA polymerase ribozymes (RPR). Specifically, to undertake research to investigate of various RNA polymerase ribozymes (RPR) discovered in the lab both in their apo- and holoenzyme form as well as (where appropriate in complex with simple peptides) leveraging the in-house strength of the LMB CryoEM facilities and expertise.

Main duties:

• To undertake research aimed at a better understanding of RNA polymerase ribozymes (RPR) structure and function through CryoEM studies of various RPR constructs• To identify, develop and apply a broad range of techniques to pursue the research objectives.• To present scientific work at seminars within the Laboratory and at external meetings.• To contribute to Laboratory-wide discussions on developments within the field. • Where appropriate, to draft scientific papers, and contribute to the overall preparation of research for publication.• To contribute to the LMB’s mission in the public engagement of science, and the translation of research findings into improvements in health care.• To assist in the training of PhD students and other members of the LMB.

Key responsibilities:

To plan your own work and objectives and manage your experimental work within the project along with your Supervisor.

To introduce and apply new techniques across a wide range of disciplines and to have the creativity and initiative to develop novel approaches and methods where required.

To ensure the research is carried out in accordance with good practice and in compliance with local policies and legal requirements.

To contribute to the smooth running of the Group, including the effective use of resources, training of others and taking responsibility for use of communal facilities.

Working relationships:

You will report to Dr Holliger and will interact and collaborate with other Postdoctoral Scientists, Research Support Staff and Students, not only in your Group, but also across the LMB and with external Groups as necessary.

Additional information:

The above lists are not exhaustive and you are required to undertake such duties as may reasonably be requested within the scope of the post. All employees are required to act professionally, co-operatively and flexibly in line with the requirements of the post and the MRC.