Discovery DMPK Lead (m/f/d)

## Opportunity Review: Driving Innovation in Drug Discovery (DMPK Specialist)

This professional, permanent, full-time hybrid role within the Research & Development department presents a compelling opportunity for experienced DMPK professionals eager to make a significant impact on patient lives. If you are driven by a passion for innovation and aspire to contribute to the development of groundbreaking medicines, this position warrants your close consideration.

The core mission of this role is to significantly influence the progression of novel treatment options, particularly in the areas of small molecules and oligonucleotides, with the ultimate goal of alleviating pain. You will be an integral part of a state-of-the-art R&D environment, collaborating with talented colleagues to translate scientific insights into tangible improvements for patients.

Key Advantages for Potential Candidates:

• Direct Impact on Patient Care: This role offers the profound satisfaction of directly contributing to the development of medicines that can change lives for the better and advance the vision of a world free of pain.
• Cutting-Edge Research Environment: You will be immersed in a state-of-the-art R&D setting, utilizing advanced computational, in vitro, and in vivo technologies.
• Cross-Functional Collaboration: The opportunity to work closely with diverse teams, including Medicinal Chemistry, Pharmacology, Genetic Medicines, Pharmaceutical Sciences, and Clinical, fosters a holistic understanding of drug development.
• Scientific Leadership: You will have the autonomy to lead the scientific and operational design, execution, and analysis of critical DMPK, ADME, and PKPD studies.
• Strategic Influence: This position empowers you to influence project progression from early discovery through candidate selection and into preclinical development, playing a key role in critical decision-making.
• Exposure to Multiple Modalities: Gain valuable experience and deepen your understanding of DMPK principles for both small molecules and oligonucleotides, a highly sought-after skillset in the industry.
• External Engagement: Opportunities to engage with Contract Research Organizations (CROs) and external consultants will broaden your network and experience in managing external partnerships.
• Continuous Learning and Publication: The role encourages staying abreast of the latest DMPK science through literature and conferences, with the potential for publishing your work, fostering professional growth.
• Hybrid Work Model: The hybrid nature of this role offers a balance between in-office collaboration and remote flexibility.

Key Considerations for Your Career Path:

• Extensive Experience Required: This role demands a strong foundation, with a minimum of 7 years of industry experience in DMPK, specifically as a DMPK project representative on discovery and development projects. A degree or PhD in a relevant scientific field is essential.
• Specialized Technical Expertise: For small molecules, a deep understanding of ADME/DMPK principles and their relation to drug design and PKPD is crucial. For oligonucleotides, a solid grasp of their specific DMPK and PKPD principles is necessary, with prior experience being a significant advantage.
• Proven Study Management Skills: Candidates must demonstrate a strong track record in designing, initiating, and overseeing DMPK/ADME studies at CROs, ensuring timely data delivery and insightful interpretation to drive optimization.
• Pharmacokinetic Analysis Proficiency: Experience with pharmacokinetic analysis and familiarity with software like Phoenix/WinNonLin PK are essential.
• Matrixed Environment Acumen: The ability to thrive and deliver in a matrix environment, managing multiple priorities and deadlines, is paramount.
• Communication and Collaboration Skills: Excellent written and verbal communication skills are vital for effective engagement with internal and external stakeholders.

As highlighted by Paul Morgan, the Hiring Manager, "DMPK sciences plays a crucial role at the interface between preclinical and clinical development. At [Company Name - *implied*], we are at an exciting phase of innovation of small molecules and genetic medicines for Pain R&D. Come join us in DMPK on this journey." This statement underscores the strategic importance of this role and the exciting scientific frontier you will be exploring.

If you are a seasoned DMPK professional seeking an opportunity to leverage your expertise in a dynamic and impactful setting, this role offers a platform for significant career advancement and the chance to contribute meaningfully to the future of medicine.