Research Associate/Fellow (Fixed term) (MED reference: MED374924

The role will provide support to an ongoing new MRC programme grant that aims to exploit a novel molecular toolkit to explore cell type specific adenosine receptor pharmacology and regulation at endogenous levels of expression.  The successful candidate will join a team of postdocs supporting this programme and will be specifically involved in the study of adenosine A2A receptor pharmacology and dimerization. The work will involve novel fluorescence based assays and state-of-the-art imaging to unravel the interaction of A2A receptors with other cell surface receptors using 3D cell culture models involving multiple cell types, such as endothelial, fibroblasts and cancers cells (for cancer models).

The role holder will work closely with a postdoctoral medicinal chemist and undertake resonance energy transfer measurements (both BRET and TR-FRET), confocal and super-resolution imaging, fluorescence correlation spectroscopy (FCS), CRISPR/Cas9 genome editing and complex molecular and cellular biology.

Candidates should have a PhD (or close to completion) or equivalent in molecular pharmacology or a related subject area, along with previous experience with using bioluminescence resonance energy transfer techniques (BRET) and both fluorescence correlation spectroscopy and photon counting histogram approaches. The candidate should also have previous research experience of the molecular pharmacological characterisation of G protein coupled receptors (GPCRs).  

The successful candidate will join a vibrant cell signalling research group within the Centre of Membrane Proteins and Receptors in Nottingham. 

This full-time (36.25 Hour), fixed-term post is available for 18 months subject to funding with commencement of post from 2 December 2024. If the start date is delayed this role must end on 31 May 2026. Job share arrangements may be considered. Requests for secondment from internal candidates may be considered on the basis that prior agreement has been sought from both your current line manager and the manager of your substantive post, if you are already undertaking a secondment role.

Informal enquiries may be addressed to Stephen Hill, email [email protected]. Please note that applications sent directly to this email address will not be accepted.

Closing Date: 18 Oct 2024 Category: Research and Teaching (R&T)