Senior Scientist, Bioconjugation - Oncology Targeted Discovery Chemistry, Early Oncology

Job Title: Senior Scientist, Bioconjugation - Oncology Targeted Discovery Chemistry, Early Oncology, London UK

Location: London

Salary: Excellent

Introduction to role:

In the Oncology Research and Development, we relentlessly follow the science, challenging the status quo to deliver more effective treatments to patients in need. Our dedication means we purposefully push back the limits of knowledge to change the practice of medicine. To ensure no patient is left behind, no matter what stage of disease. Fast-paced, it takes agility and responsiveness to stay committed in our pursuit of excellence. We work with focus to seek the unanswered questions – innovating, exciting accepted norms, quick decision-making and taking smart risks. A place of trust, its an opportunity to take accountability, be brave, speak up, step up and redefine Oncology, now and in the future. Be a part of improving lives. This is the time to join the team who is confident that cures for cancer are within our grasp

This is an exciting opportunity for a highly motivated laboratory-based scientist to join the Bioconjugation group in Oncology Targeted Discovery (OTD) - Chemistry Site, London, UK. You will be part of a team of Bioconjugation scientists working collaboratively with other subject areas, playing a pivotal role in the delivery of robust and high-quality data to support Antibody Drug Conjugate (ADC) discovery projects within the Oncology portfolio. You should have a background in Oncology/Biology/Chemical Biology and a strong passion for experimental work and delivering data from the laboratory. You will authoritatively design and conduct laboratory experiments, develop analytical methods, analyse and report experimental data, use scientific judgment, and communicate effectively to relevant partners and supply to early-stage drug discovery decision making.

Accountabilities:

This is a full-time laboratory-based position to develop, optimise and scale up drug discovery research lab experiments independently by applying the techniques of Bioconjugation of small molecules to antibodies and related scaffolds

Perform routine interpretation of data with little or no guidance, with a clear understanding of its implications within drug discovery and effectively communicate to relevant partners in a clear and concise manner

Work independently within a team and collaboratively with internal and external partners

Maintain a well-developed understanding of approaches to targeted delivery of therapeutics within Oncology

Remain up to date with relevant recent advances and relevant technology including published papers/patents with peers

Authoring and reviewing relevant documents including laboratory notebooks, protocols and reports

Ensures own work, and work of peers, follows Good Laboratory Practice, Safety, Health and Environment standards and all other relevant internal AstraZeneca standards and external regulations

Essential Skills/Experience:

PhD or equivalent experience in Chemistry, Biochemistry, Bio/Chemical engineering or relevant subject area or M.Sc/B.Sc in above fields with relevant industrial experience

Strong background in chemistry and protein biochemistry

Hands on experience in protein/bioconjugate characterisation by UV/Vis spectroscopy, size-exclusion/hydrophobic interaction/ion exchange chromatography HPLC and LCMS

Experience with completing preparative chromatography purifications using AKTA and TFF systems

A track-record of protein/related scaffold modification experience

Desirable Skills/Experience:

Experience with Antibody-drug conjugates

Knowledge and strong understanding of developing and optimising robust analytical methods for protein/bioconjugate characterisation

Biophysical Characterization of protein/related conjugates

So, whats next?

Please complete your application before the below closing date ( 21 March 2025)

We look forward to hearing from you.

Where can I find out more?

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Join us today and be a part of the change!

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.