Process Engineer, AstraZeneca

Process Engineer – Global Product Development

Location:Macclesfield, UK

Join a company where science becomes medicine. At AstraZeneca, we transform breakthrough ideas into life‑changing therapies. Our Macclesfield Campus in Cheshire is a vibrant hub of scientific excellence, collaboration, and cutting‑edge manufacturing—where your work will directly impact patients worldwide.

About Pharmaceutical Technology & Development (PT&D) and Global Product Development (GPD)

PT&D is the bridge that turns brilliant science into real medicines, spanning the entire value chain—from early toxicology and clinical supplies to technology that enables robust commercial manufacture. Within PT&D, GPD leads the late‑stage design and development of drug products across a range of dosage forms. We develop the formulation, manufacturing process, and scientific understanding needed to scale, launch, and sustain new medicines. Youll collaborate in highly multidisciplinary teams with engineers and pharmaceutical scientists to deliver for patients.

The Opportunity

We are seeking a Process Engineer focused onoral solid dose (OSD)forms (tablets, capsules). You will split your time between lab‑based experimentation and in silico process development, and supporting project teams onscale‑upandtechnology transferto manufacturing sites. Flexibility to contribute to other dosage forms (e.g., parenterals) may be required. This role is ideal for someonecurious, motivated, and eager to learn.

You will play a key part in advancing ourcontinuous manufacturing platforms—a strategic priority for AstraZeneca and PT&D—delivering experimental and digital insights to develop, optimize, and scale robust, sustainable processes across diverse unit operations.

Key Responsibilities

Lab-based process development:Plan and execute laboratory‑scale OSD process experiments, with an emphasis on continuous manufacturing.Data and digital delivery:Analyze and interpret data; applymodelling and simulationto guide process understanding and decision‑making; communicate clear, robust conclusions.Project support:Provideprocess engineering expertiseto project teams, includingtechnical risk assessments,scale-up,tech transfer, and preparation of documentation for manufacturing sites.Cross-functional collaboration:Contribute to integrated drug product development plans within amultidisciplinary team.Manufacturing learning:Capture learnings from manufacturing runs and driveprocess improvements.Problem solving:Troubleshoot issues arising during development and manufacturing.Lab ownership: Maintain lab spaces and equipment, ensuring safety, validation/calibration, and continuous improvement.Sustainability:Support initiatives to improveenvironmental sustainability,efficiency, andcost.

Essential Skills and Experience

Degree:Chemical Engineering or equivalent.Process engineering fundamentals:Strong understanding of unit operations applicable to pharmaceutical processing, including scale and equipment dependencies.Technology and manufacturing knowledge:Broad familiarity with process equipment, technologies, and manufacturing principles.Scientific rigor:Ability to work to high standards of documentation and experimental quality, independently and within teams.Data-driven judgement:Rational problem-solving and decision-making grounded in data.Collaboration and communication:Clear, proactive communication and teamwork.

Desirable Skills and Experience

OSD unit operations:Hands-on experience in powder mixing/blending, continuous feeders/blenders, granulation, compression, or coating.Pharmaceutical development exposure:Understanding of drug product development lifecycle.Continuous manufacturing:Experience at lab or manufacturing scale.Lab operations/GMP exposure:Laboratory processing and/or familiarity withGMPenvironments.Data and modelling:Experience in data analysis, modelling, or simulation.

What You Can Expect

Youll work on live development projects across a diverse portfolio—gaining hands‑on experience in OSD manufacturing and its industrial applications and collaborating with a broad range of disciplines.

In addition, you can expect:

Tailored training:A comprehensive program to build technical depth and leadership capability.Career growth:Opportunities to broaden your experience as the role progresses.Competitive rewards:Salary and benefits that reflect your impact.

Join us to reset expectations of what a biopharmaceutical company can be and help deliver the next generation of medicines. Interested? Apply now and be part of our journey.

Date Posted

09-Dec-2025

Closing Date

23-Dec-2025

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.